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42% of Drug Reactions Are Vaccine Related, Groundbreaking Chinese Study Finds

by Sayer Ji
See all TBYIL articles by Sayer Ji

(The Best Years in Life ) A groundbreaking new drug safety study published in the open access journal PLoS and titled, "Adverse Drug Reactions of Spontaneous Reports in Shanghai Pediatric Population," has revealed for the first that that 42.5% of all reported adverse drug reactions occurring in 2009 in a Chinese pediatric population (Shanghai, pop of 17 mil) were caused by vaccines, with reactions as severe as anaphylaxis and death.

The report carries unique gravitas insofar as the data was gathered through spontaneous reports of physicians (52.03%), pharmacists (24.27%) and other health care practitioners (15.46%), with only 2.52% coming from 'consumers.' Presumably, the clinical training of those reporting gives the study additional credibility.

According to the study, which is one of the first ever conducted on the topic in China, "Knowledge of drug safety in the pediatric population of China is limited. This study was designed to evaluate ADRs in children reported to the spontaneous reporting system (SRS) of Shanghai in 2009."

 

The results of the study were reported as follows:

"A male overrepresentation was observed regarding the total number of reports. The most frequently reported group of drugs were vaccines (42.15%). Skin rash and fever were the commonest symptoms reported in the total pediatric dataset. The proportion of children that suffered from a serious ADR was 2.16% and that for drug related deaths was 0.34%. And we found that the multiple drug exposure experienced a high proportion of serious ADRs compared with the single drug use (χ215.99, P<0.0001). Sixty-five percent of ADRs were for children less than 6 years of age. And more than half of reports were from doctors."

According to the study, the World Health Organization defines adverse drug reaction (ADRs) "...as events related to a medication that are noxious, unintended and occur at normal doses used in humans for prophylaxis, diagnosis or therapy of disease, or for modification of physiological function."  Their definition excludes accidental or deliberate excessive dosage or maladministration. The global problem with ADRs is so serious that, according to the study, "ADRs are one of the leading causes of morbidity and mortality in many countries [2], [3]."  Indeed, a 1998 report published in JAMA found that 106,000 Americans die every year from correctly prescribed medications.

The study results showed concerning patterns, across both age and gender.

  • The Younger The More Susceptible To Harm: "When the data were assessed in terms of age groups, almost two thirds of ADRs were reported for children from birth to 5 years of age (65.01%) and 39.46% concerned children aging 2 months-2 years." Furthermore, "The highest proportion (6.58%) of serious reports was reported for newborn (0–1 month)."
  • The Males Were More Susceptible Than Females: In general, a total of 1790 ADRs (40.41%) and 2640 ADRs (59.59%) were reported for female and male patients, respectively.

In interpreting the results, one explanation offered by the authors for the fact that 50% of the ADRs were reported for children from birth to 5 years of age, with close to 40% affecting children between 2 months and 2 years of age, was "Children under 5 were the most common age group for vaccination." 

They expanded on this explanation further:

"The ADR rate causes by vaccine is much higher than other drugs, and this may be related to the types and number of vaccination being used in China, as the types of routine immunization vaccines in China reach up to 15 kinds, which is much higher than 7 kinds in India and Vietnam, 9 kinds in Thailand and 11 kinds in America, and most of the vaccines in China are attenuated live vaccines, which may bring greater potential safety hazard."

See Also:

The Five Things Your REALLY Need to Know about HPV Vaccines

Welcome to "The Golden Era” of Vaccines

Mainstream Support of Vaccinations - Another Chapter in an Old Story

Original article source: http://www.greenmedinfo.com/blog/42-drug-reactions-are-vaccine-related-groundbreaking-chinese-study-finds

sayerji

The Best Years in Life
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