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The Bell Shaped Curve
Remarkable British Medical Journal Paper shows Vitamin A Limits Vitamin D Cancer Benefits
by John Cannell, MD
Vitamin D Council) A few weeks ago, the British Medical Journal
published a remarkable paper, remarkable that it studied more than 500,000
subjects, remarkable that it had 56 (fifty-six) authors, remarkable that it
confirmed low vitamin D levels obtained in the past are a risk factor for
developing colon cancer in the future. However, the most remarkable part of
the paper is that the 46 scientists minimized the true significance of their
own research. They found that vitamin A, even in relatively low amounts,
appears to thwart vitamin D's association with reduced rates of colon
a prospective nested case-controlled study, which means it uses subject's
vitamin D blood samples obtained and frozen in the past and then reviews
their medical records into the future to see who gets colon cancer,
comparing the study subjects to similar members of the group that did not
get the illness. Dr. Mazda Jenab and his 45 colleagues from the
International Agency for Research on Cancer confirmed that low vitamin D
levels are a risk for colon cancer in a dose response manner; those with the
highest levels were about twice as less likely to develop colon cancer
compared to those with the highest levels.
Prostate cancer is another good example; ten similar studies have been
conducted on vitamin D blood levels and the risk of subsequent prostate
cancer. Dr. Lu Yin of the German Cancer Research Center reviewed them in
detail. Eight of the studies found no relationship but two studies found a U
shaped curve, that is, an increased risk of prostate cancer at both lower
and higher vitamin D levels. You guessed it; both of these studies were from
Nordic countries where cod liver oil consumption is rampant.
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Zhou W et al. Circulating 25-hydroxyvitamin D levels predict survival in
early-stage non-small-cell lung cancer patients. J Clin Oncol. 2007 Feb
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