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New
Study Says Antidepressant Drugs Next to Worthless
More Bad News for Paxil
by Tony Isaacs
A
new study published in the Journal of the American
Medical Association found that the antidepressant drugs
paroxetine and imipramine do not help patients with
mild, moderate and even severe depression much more than
an inactive placebo.
"They would have done just as well or just about as well
with a placebo," concluded Robert DeRubeis, a
psychologist at the University of Pennsylvania,
Philadelphia who performed the meta-analysis with along
with colleagues.
The meta-analysis combined data from six studies with
over 800 combined patients. Those with initial
depression scores of 23 or below dropped an averaged 8
points when given antidepressants compared to a drop of
7 points for those given a placebo. According to
DeRubeis, the study should give pause doctors and
patients weighing antidepressants, and he suggested that
consideration be given to other alternatives such as
exercise, psychotherapy, and even "self-treatment"
Paroxetine is one of a widely sold class of drugs known
as selective serotonin reuptake inhibitors and is better
known as the brand name sold by GlaxoSmithKline: Paxil.
Imipramine is an older tricyclic antidepressant drug
which was developed in the 1950s.
Glaxo spokeswoman Sarah Alspach responded by saying that
the study "contributes to the extensive research" into
antidepressants, noting that Paxil received U.S.
government approval in 1992. She continued to maintain
that Paxil has helped "millions of people battling
mental illness.
The study is the latest in a long string of bad news
that has been reported about Paxil. Since Paxil`s
introduction on the market in 1993, the potentially
dangerous drug has been plagued with complaints of
serious adverse medical events including an increase in
suicide rates and attempts, addiction, and birth
defects.
In 2005, after Glaxo had denied repeated reports of
Paxil causing addiction and severe withdrawal effects, a
federal judge ordered the maker to stop all television
commercials nationwide that say the drug is not
habit-forming. The ruling came after a class-action
lawsuit was filed on behalf of 35. According to the
judge`s ruling, the commercials were "misleading and
created inaccurate expectations about the ease of
withdrawal from the drug". It is reported that Glaxo has
settled nearly 3,200 cases involving addiction-related
complaints and complications.
Glaxo has also reportedly settled 150 Paxil-related
suicide cases and 300 Paxil-related suicide attempts
thus far. In most instances, Glaxo attempted to blame
the suicides on the underlying depression and not the
drug itself. Paxil has also been linked to severe
birth-defects in children whose mothers took the
antidepressant while pregnant. Last October, a
Philadelphia jury found that Glaxo negligently failed to
warn doctors of Paxil`s risk to pregnant women and
awarded $2.5 million to the parents of a three year old
boy. According to reports, this case was the first of
some 600 lawsuits against Glaxo for failing to warn of
Paxil`s dangers to pregnant women. Reports also indicate
that Glaxo has settled at least 10 other birth-defect
cases to date.
Paxil lawsuits and settlements have been estimated to
cost Glaxo a staggering $1 Billion in settlements thus
far, an amount that is nevertheless dwarfed by the many
billions of dollars in profits Glaxo has received from
Paxil sales.
Meanwhile, despite all the deaths, injuries and
lawsuits, Paxil continues to have FDA approval,
continues to downplay harmful side effects and continues
to be highly promoted, the same as happened in the Vioxx
scandal and with other harmful drugs. The Associated
Press reported in August of last year that
GlaxoSmithKline commissioned sales reps to recruit
doctor-authors for ghostwritten articles supporting
Paxil use. Glaxo even named the program after everyone's
favorite friendly ghost and called it the "CASPPER"
program..
Sources included:
http://www.msnbc.msn.com/id/34712755/ns/health-mental_health/
www.usatoday.com/news/health/2002-08-20-paxil-ads_x.htm
www.usatoday.com/news/.../2002-07-08-antidepressants.htm
http://www.fiercepharma.com/story/ap-glaxo-reps-aided-paxil-ghostwriting/2009-08-20
http://www.flainjurylawyerblog.com/2009/12/paxil-lawsuits-costing-manufac.html
For the best in health information, subscribe to The Rose Laurel Press Newsletter featuring articles by Tony M. Isaacs
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