Stops Lung Cancer in Cigarette Smokers
by Barbara Minton
TBYIL articles by Barbara Minton
simple substance found in food , known as inositol, appears to reverse the
harmful effects of smoking, a finding that can bring cheer to anyone who
smokes or loves someone who does. Lung cancer is the leading cause of cancer
related death in the U.S., and 85 to 90% of lung cancer cases are associated
with tobacco use, so this discovery is a very big deal. Tobacco components
promote the initiation and growth of lung tumors through their toxic effects
on genes as well as through biochemical modulation of signaling pathways
that regulate cell proliferation and survival. Inositol seems to stop these
processes dead in their tracks.
Inositol is a naturally occurring nutrient grouped with the B complex of
vitamins, even though it is not officially recognized as a vitamin and no
RDA has been set. Like the B vitamins, inositol is water soluble and as a
result is not stored very well in the body. Even though approximately 4
grams a day are naturally produced from glucose in the kidneys, this amount
does not meet the body’s needs, and more must be obtained from the diet.
Inositol is found in the form of phytic acid or phytate in a variety of
foods such as nuts, seeds, oats, rice, beans, corn, chickpeas, liver, pork,
veal, and whole grains. However in this form it is not readily bioavailable.
The best sources of inositol are fruits (particularly cantaloupe and citrus
fruits) and lecithin granules, because their form of inositol is highly
bioavailable. Inositol is available as a supplement in capsule or powdered
form. Inositol powder has a delicious sweet, creamy taste and can be easily
added to smoothies or eaten alone.
Two famous researchers discovered inositol prevents cancer
Dr. Lee Wattenberg, known as the father of chemoprevention, searched for
several decades starting in the 1970`s to find naturally occurring compounds
that could theoretically prevent cancer and applied scientific methodologies
to research his discoveries. After testing several molecules, he found
inositol showed great promise. Using various study models he was able to
demonstrate that inositol could prevent lung cancer. It had previously been
documented that a poor diet increased the chances for cancer to occur, but
Dr. Wattenberg was among the first to show that a common nutrient could
actually prevent cancer.
A few years later, Dr. Abdul Kalam Shamsuddin, known as the father of IP6 (inositol
hexaphosphate), also showed that inositol was able to prevent cancer,
demonstrating the preventive value of the compound with colon cancer.
Research by Dr. Shamsuddin revealed that inositol affects health in several
ways, largely because it is in all human cells and is a major component of
cell linings or membranes where it facilitates communication between the
various organelles and molecules in the cell signaling process.
THRIVE MARKET - GOOD FOR YOU AND YOUR WALLET
Join Us and Get Your Favorite Organic Foods & Non-GMO Brands Delivered to Your
Why don`t cigarette companies hand out a bottle of inositol
with each carton of cigarettes?
Some bright young executive at one of the major tobacco companies has probably
had the idea to boost sales by telling everybody that inositol, an inexpensive
supplement, could prevent lung cancer. But for the cigarette companies to buy
into the idea would mean an acknowledgement that cigarettes do cause cancer.
Such an acknowledgement would create immense legal liability for any company
making and selling cigarettes.
Inositol provides many other benefits
Inositol is a critical nutrient for hair growth. It helps prevent hardening of
the arteries and is important in the formation of lecithin and in the metabolism
of fats and cholesterol. Inositol has a calming effect on the brain and has been
used successfully at high doses as a treatment for psychiatric disorders such as
depression, bipolar, obsessive-compulsive, and panic attacks. Inositol is also
used for insomnia, retinopathy, bulimia nervosa and binge eating. It is
beneficial for diabetic neuropathy, brain seizures, and for normalizing
cholesterol and triglyceride levels.
Symptoms of deficiency are arteriosclerosis, constipation, hair loss, high blood
cholesterol, irritability, mood swings, and skin eruptions.
The consumption of large amounts of caffeine usually results in inositol
deficiency. As coffee consumption was often accompanied by cigarette smoking,
this shortage of inositol may have been a critical factor in the cases of
smoking induced lung cancer so prevalent during the time when smoking was in
Research continues to refine knowledge of the mechanisms by which inositol
Inositol is a natural compound and therefore not able to be patented by drug
companies, so there is little incentive for studies of it. However, some
dedicated researchers are continuing to study the effects of inositol, trying to
determine the specific mechanisms by which it prevents lung cancer in cigarette
smokers. Here are summaries of the abstracts from the most recent research. It
is truly amazing, or maybe criminal is a better word, that the smoking public
has not been made aware of these results which date back steadily to the time of
Drs. Watterberg and Shamsuddin.
The most recent studies are based on those that have gone before in an effort to
refine the knowledge of how inositol affects pathway activation in the
development of lung cancer. The phosphatidyl-inositol-3-kinase-AKT pathway is
emerging as an important regulator of tumor cell survival.
Researchers at Boston University Medical Center have observed a significant
increase in activation of another pathway, phosphatidylinositol 3-kinase (PI3K),
in the bronchial airway of smokers with lung cancer and dysplastic lesions,
suggesting that PI3K is activated in the airway before a tumor beings. Further,
these researchers found that when PI3K is decreased in the airway of high risk
smokers by the use of inositol treatments, their dysplasia is regressed. They
also noted the PI3K pathway was inhibited by inositol in vitro, and concluded
that the deregulation of the PI3K pathways in the bronchial airway epithelium of
smokers is an early, measurable and reversible event in the development of lung
In older research, scientists at the National Cancer Institute in Maryland have
also studied the pathways through which genes are damaged by tobacco smoking and
the pathways that regulate cancerous cell proliferation and survival. After a
review of data, they described the cell surface receptors and other upstream
components required for tobacco carcinogen-induced activation of the Akt and
mTOR pathways and the positive effects of inositol and other treatments upon
In the journal Biochemical Pharmacology (December,2008) researchers reported
inositol potentiating appropriate cell death. This effect correlated with
down-regulation of various gene products that mediate cell survival,
proliferation, metastasis, and invasion, all known to be regulated by NF-kappaB
(a transcription factor that enhances production of inflammatory mediators).
Inositol blocked NF-kappaB activation induced by cigarette smoke.
Cancer Epidemiology Biomarkers and Prevention (August, 2006) reported a clinical
study conducted to assess the safety, tolerability, maximum tolerated dose, and
potential chemopreventive effects of inositol in smokers with bronchial abnormal
cell development. Smokers between the ages of 40 and 74 participated in dose
escalation ranging from 12 to 30 grams per day of inositol for a month to
determine the maximum dose tolerated, which turned out to be 18 grams per day.
Ten new subjects were then enrolled to take the maximum tolerated dose for 3
months. Side effects, when present, were mild and mainly gastrointestinal in
nature. A significant rate of reduction in abnormal cells was observed (91%
compared to 48% in the controls). A significant reduction in systolic and
diastolic blood pressure by an average of 10mm Hg was also observed after taking
18 grams per day of inositol for a month or more.
Researchers acknowledged that chronic exposure of mice and rats to cigarette
smoke affects T-cell responsiveness which may account for the decreased T-cell
proliferative and T-dependent antibody responses in humans and animals exposed
to cigarette smoke. In a study reported in the Journal of Pharmacology and
Experimental Therapeutics, April 2000 researchers sought to discover the
mechanism by which cigarette smoke affects T cell function. They found that
spleen cells from animals with chronic nicotine exposure have depleted inositol
stores and a decreased ability to raise intracellular calcium levels. Their
results suggest that chronic smoking causes T cell energy reduction and
inactivity by impairing pathways and depleting stored inositol resulting in a
diminished level of inositol-sensitive calcium.
Mice were fed a diet supplemented with inositol and exposed for 5 months to a
mixture of sidestream and mainstream cigarette smoke, in a study reported in
Carcinogenesis, July, 1999. In the animals fed the control diet alone, the
average number of manifest lung tumors was 2.1. In the animals given the control
diet plus an inositol mixture, the number of manifest lung tumors was 1.0.
Researchers concluded that inositol constitutes an effective prevention regimen
against the initiation of tobacco induced lung tumors.
The Best Cancer Fighting and Immune Boosting Food
Choices for Beating and Avoiding Cancer
A Good Cancer-Fighting Foundation Will Ensure Victory
The Best Years in Life Cancer Alternatives Resource Page
For more information:
Originally published at alignlife.com
Barbara is a school psychologist and the author of Dividend Capture, a book on personal finance. She is a breast cancer survivor using bioidentical hormone therapy, and a passionate advocate of natural health with hundreds of articles on many aspects of health and wellness. She is the editor and publisher of AlignLife's Health Secrets Newsletter.
See other articles by the Barbara Minton here:
Natural News: http://www.naturalnews.com/author358.html
To see the latest items on sale at
Utopia Silver. click on the above link, or click