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The Best Years in Life Anvirzel Case Reports and Oleander Studies
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Anvirzel case reports and the oleander and related studies of MD Anderson researcher Dr. Robert Newman
Unknown to many people, a patented
medicine version of oleander extract named Anvirzel has been used outside the
United States for over 40 years. The man who re-discovered the age old oleander
remedy and developed Anvirzel is Doctor H Z Ozel. Since the medicine he used is
essentially the same as the home remedy version and the even better Sutherlandia
OPC supplement (http://www.sutherlandiaopc.com), I thought it might be
educational to list links to some of his case histories: Adenocarcinoma (epithelial type malignant mesothelioma?) - US Small cell anaplastic carcinoma in the lung -YG Malignant lymphoma, lung cancer - MG Prostate cancer with bone metastases - KE Pancreas cancer with bone metastases - SO Inoperable stomach carcinoma with metastases -VO Breast cancer (Ductal carcinoma) - SE Source: http://www.drozel.org/eng/case_reports.htm And here is a partial list of studies on oleander, Anvirzel and cardiac glycosides: Newman studies involving Anvirzel, oleander and cardiac glycosides found in oleander
1:
Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C,
Chan D, Johansen M, Yang P.
Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside. Integr Cancer Ther. 2007 Dec;6(4):354-64. PMID: 18048883 [PubMed - indexed for MEDLINE]
2:
Ni D, Madden TL, Johansen M, Felix E, Ho DH, Newman RA.
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander. J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85. PMID: 12416031 [PubMed - indexed for MEDLINE]
3:
Smith JA, Madden T, Vijjeswarapu M, Newman RA.
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin. Biochem Pharmacol. 2001 Aug 15;62(4):469-72. PMID: 11448457 [PubMed - indexed for MEDLINE]
4:
Pathak S, Multani AS, Narayan S, Kumar V, Newman RA.
Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. Anticancer Drugs. 2000 Jul;11(6):455-63. PMID: 11001386 [PubMed - indexed for MEDLINE]
5:
Wang X, Plomley JB, Newman RA, Cisneros A.
LC/MS/MS analyses of an oleander extract for cancer treatment. Anal Chem. 2000 Aug 1;72(15):3547-52. PMID: 10952541 [PubMed - indexed for MEDLINE]
6:
Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB.
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. Cancer Res. 2000 Jul 15;60(14):3838-47. PMID: 10919658 [PubMed - indexed for MEDLINE]
7:
Newman RA, Yang P, Pawlus AD, Block KI.
Cardiac glycosides as novel cancer therapeutic agents. Mol Interv. 2008 Feb;8(1):36-49. PMID: 18332483 [PubMed - in process]
8:
Newman RA, Yang P, Hittelman WN, Lu T, Ho DH, Ni D, Chan
D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E,
Addington C.
Oleandrin-mediated oxidative stress in human melanoma cells. J Exp Ther Oncol. 2006;5(3):167-81. PMID: 16528968 [PubMed - indexed for MEDLINE]
9:
Nasu S, Milas L, Kawabe S, Raju U, Newman R.
Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. Cancer Lett. 2002 Nov 28;185(2):145-51. PMID: 12169388 [PubMed - indexed for MEDLINE]
10:
McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA.
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res. 2000 Jul 15;60(14):3807-12. PMID: 10919654 [PubMed - indexed for MEDLINE]
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