Anvirzel Case Reports and Related PubMed Indexed Studies on Oleander

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For a complete natural anti-cancer protocol featuring oleander, click HERE.

Unknown to many people, a patented medicine version of oleander extract named Anvirzel has been used outside the United States for over 40 years.  The man who re-discovered the age old oleander remedy and developed Anvirzel is Doctor H Z Ozel.  Since the medicine he used is essentially the same as the home remedy version and the even better Sutherlandia OPC supplement (, I thought it might be educational to list links to some of his case histories:


Mesothelioma - HD

Adenocarcinoma (epithelial type malignant mesothelioma?) - US

Small cell anaplastic carcinoma in the lung -YG

Malignant lymphoma, lung cancer - MG

Prostate cancer with bone metastases - KE

Pancreas cancer with bone metastases - SO

Pancreas cancer - MH

Peritoneal carcinosis - HA

Inoperable stomach carcinoma with metastases -VO

Brain tumor - AS

Brain tumor - SD

Breast cancer (Ductal carcinoma) - SE

Antrum cancer - YT

Brain tumor - EO


And here is a partial list of studies on oleander, Anvirzel and cardiac glycosides:

Newman studies involving Anvirzel, oleander and cardiac glycosides found in oleander

1: Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P. 

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Integr Cancer Ther. 2007 Dec;6(4):354-64.

PMID: 18048883 [PubMed - indexed for MEDLINE]

2: Ni D, Madden TL, Johansen M, Felix E, Ho DH, Newman RA. 

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.

PMID: 12416031 [PubMed - indexed for MEDLINE]

3: Smith JA, Madden T, Vijjeswarapu M, Newman RA. 

Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.

Biochem Pharmacol. 2001 Aug 15;62(4):469-72.

PMID: 11448457 [PubMed - indexed for MEDLINE]

4: Pathak S, Multani AS, Narayan S, Kumar V, Newman RA. 

Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

Anticancer Drugs. 2000 Jul;11(6):455-63.

PMID: 11001386 [PubMed - indexed for MEDLINE]

5: Wang X, Plomley JB, Newman RA, Cisneros A. 

LC/MS/MS analyses of an oleander extract for cancer treatment.

Anal Chem. 2000 Aug 1;72(15):3547-52.

PMID: 10952541 [PubMed - indexed for MEDLINE]

6: Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB. 

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Cancer Res. 2000 Jul 15;60(14):3838-47.

PMID: 10919658 [PubMed - indexed for MEDLINE]

7: Newman RA, Yang P, Pawlus AD, Block KI. 

Cardiac glycosides as novel cancer therapeutic agents.

Mol Interv. 2008 Feb;8(1):36-49.

PMID: 18332483 [PubMed - in process]

8: Newman RA, Yang P, Hittelman WN, Lu T, Ho DH, Ni D, Chan D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E, Addington C. 

Oleandrin-mediated oxidative stress in human melanoma cells.

J Exp Ther Oncol. 2006;5(3):167-81.

PMID: 16528968 [PubMed - indexed for MEDLINE]

9: Nasu S, Milas L, Kawabe S, Raju U, Newman R. 

Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.

Cancer Lett. 2002 Nov 28;185(2):145-51.

PMID: 12169388 [PubMed - indexed for MEDLINE]

10: McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA. 

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.

Cancer Res. 2000 Jul 15;60(14):3807-12.

PMID: 10919654 [PubMed - indexed for MEDLINE]

Other Studies:

"Bioactive cardenolides from the stems and twigs of Nerium oleander."

"Bioactive pregnanes from Nerium oleander"

See also:

Oleander Extract for Cancer Successfully Passes Phase I FDA Trial

Sutherlandia OPC Oleander Based Supplements

Be sure to read the entire Oleander Series of articles:

An Amazing Discovery in Turkey

The Father of Oleander Soup

The History of Oleander Before 1960

Success Against Cancer and HIV in South Africa

How to Make Homemade Oleander Extract - Part 1

How to Make Homemade Oleander Extract Part 2 - Tips and Advice

Oleander Induces Autophagy in Cancer Cells - Exclusive Story

Case Reports and Studies on Oleander

Herbal Supplement for HIV/AIDS is Successful in Clinical Trial

Unraveling the Mysteries of the Cancer Fighting Oleander Plant

Two Oleander HIV Success Stories from Africa

A Wonderful Advanced Brain Cancer Success Report Plus Dr. Swanepoel's Anti-Cancer Protocol

Unsolicited Testimonials about Sutherlandia OPC, Rose Laurel Skin Ointment and Other Oleander Based Supplementation

Testimonials From People Who Have Used Oleander Based Supplements for HIV/AIDS

Oleander Extract for Cancer Successfully Passes Phase I FDA Trial

A Brief Discussion on Oleander's Effectiveness Against Cancer

Doctor Marc Swanepoel's Suggested Protocol for Oleander Supplementation

Oleander Extract: How This Traditional Turkish Remedy Fights Cancer & Other Disease


See more natural health articles Here.


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