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Anvirzel Case Reports and Oleander Studies

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Anvirzel Case Reports and Related PubMed Indexed Studies on Oleander

Unknown to many people, a patented medicine version of oleander extract named Anvirzel has been used outside the United States for over 40 years.  The man who re-discovered the age old oleander remedy and developed Anvirzel is Doctor H Z Ozel.  Since the medicine he used is essentially the same as the home remedy version and the even better Sutherlandia OPC supplement (, I thought it might be educational to list links to some of his case histories:


Mesothelioma - HD

Adenocarcinoma (epithelial type malignant mesothelioma?) - US

Small cell anaplastic carcinoma in the lung -YG

Malignant lymphoma, lung cancer - MG

Prostate cancer with bone metastases - KE

Pancreas cancer with bone metastases - SO

Pancreas cancer - MH

Peritoneal carcinosis - HA

Inoperable stomach carcinoma with metastases -VO

Brain tumor - AS

Brain tumor - SD

Breast cancer (Ductal carcinoma) - SE

Antrum cancer - YT

Brain tumor - EO


And here is a partial list of studies on oleander, Anvirzel and cardiac glycosides:

Newman studies involving Anvirzel, oleander and cardiac glycosides found in oleander

1: Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P. 

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Integr Cancer Ther. 2007 Dec;6(4):354-64.

PMID: 18048883 [PubMed - indexed for MEDLINE]

2: Ni D, Madden TL, Johansen M, Felix E, Ho DH, Newman RA. 

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.

PMID: 12416031 [PubMed - indexed for MEDLINE]

3: Smith JA, Madden T, Vijjeswarapu M, Newman RA. 

Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.

Biochem Pharmacol. 2001 Aug 15;62(4):469-72.

PMID: 11448457 [PubMed - indexed for MEDLINE]

4: Pathak S, Multani AS, Narayan S, Kumar V, Newman RA. 

Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

Anticancer Drugs. 2000 Jul;11(6):455-63.

PMID: 11001386 [PubMed - indexed for MEDLINE]

5: Wang X, Plomley JB, Newman RA, Cisneros A. 

LC/MS/MS analyses of an oleander extract for cancer treatment.

Anal Chem. 2000 Aug 1;72(15):3547-52.

PMID: 10952541 [PubMed - indexed for MEDLINE]

6: Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB. 

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Cancer Res. 2000 Jul 15;60(14):3838-47.

PMID: 10919658 [PubMed - indexed for MEDLINE]

7: Newman RA, Yang P, Pawlus AD, Block KI. 

Cardiac glycosides as novel cancer therapeutic agents.

Mol Interv. 2008 Feb;8(1):36-49.

PMID: 18332483 [PubMed - in process]

8: Newman RA, Yang P, Hittelman WN, Lu T, Ho DH, Ni D, Chan D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E, Addington C. 

Oleandrin-mediated oxidative stress in human melanoma cells.

J Exp Ther Oncol. 2006;5(3):167-81.

PMID: 16528968 [PubMed - indexed for MEDLINE]

9: Nasu S, Milas L, Kawabe S, Raju U, Newman R. 

Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.

Cancer Lett. 2002 Nov 28;185(2):145-51.

PMID: 12169388 [PubMed - indexed for MEDLINE]

10: McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA. 

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.

Cancer Res. 2000 Jul 15;60(14):3807-12.

PMID: 10919654 [PubMed - indexed for MEDLINE]

Other Studies:

"Bioactive cardenolides from the stems and twigs of Nerium oleander."

"Bioactive pregnanes from Nerium oleander"

See also:

Oleander Extract for Cancer Successfully Passes Phase I FDA Trial

Sutherlandia OPC Oleander Based Supplements

Be sure to read the entire Oleander Series of articles:

An Amazing Discovery in Turkey

The Father of Oleander Soup

The History of Oleander Before 1960

Success Against Cancer and HIV in South Africa

The Recipe for Oleander Soup Part 1

The Recipe for Oleander Soup Part 2 - Tips and Advice

Oleander Induces Autophagy - Exclusive Story

Case Reports and Studies on Oleander

Herbal Supplement for HIV/AIDS is Successful in Clinical Trial

Unraveling the Mysteries of the Cancer Fighting Oleander Plant

Two Oleander HIV Success Stories from Africa

Unsolicited Testimonials about the Sutherlandia OPC Oleander Based Supplement



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