Anvirzel (A Patented 100% Oleander Extract) Case Reports
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(The Best Years in Life) Unknown to many people, a patented medicine version of oleander extract named Anvirzel has been used outside the United States for over 50 years. The man who re-discovered the age old oleander remedy and developed Anvirzel is Doctor Hussein Zima Ozel. Since the medicine he used is essentially the same as the home remedy version and the even better Sutherlandia OPC supplement, I thought it might be educational to list links to some of his case histories as well as links to some of the many studies which have been conducted on oleander:
And here is a partial list of studies on oleander, Anvirzel and cardiac glycosides:
Newman studies involving Anvirzel, oleander and cardiac glycosides found in oleander
Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.
Integr Cancer Ther. 2007 Dec;6(4):354-64.
PMID: 18048883 [PubMed - indexed for MEDLINE]
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.
J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.
PMID: 12416031 [PubMed - indexed for MEDLINE]
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.
Biochem Pharmacol. 2001 Aug 15;62(4):469-72.
PMID: 11448457 [PubMed - indexed for MEDLINE]
Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.
Anticancer Drugs. 2000 Jul;11(6):455-63.
PMID: 11001386 [PubMed - indexed for MEDLINE]
LC/MS/MS analyses of an oleander extract for cancer treatment.
Anal Chem. 2000 Aug 1;72(15):3547-52.
PMID: 10952541 [PubMed - indexed for MEDLINE]
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
Cancer Res. 2000 Jul 15;60(14):3838-47.
PMID: 10919658 [PubMed - indexed for MEDLINE]
Cardiac glycosides as novel cancer therapeutic agents.
Mol Interv. 2008 Feb;8(1):36-49.
PMID: 18332483 [PubMed - in process]
Oleandrin-mediated oxidative stress in human melanoma cells.
J Exp Ther Oncol. 2006;5(3):167-81.
PMID: 16528968 [PubMed - indexed for MEDLINE]
Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.
Cancer Lett. 2002 Nov 28;185(2):145-51.
PMID: 12169388 [PubMed - indexed for MEDLINE]
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.
Cancer Res. 2000 Jul 15;60(14):3807-12.
PMID: 10919654 [PubMed - indexed for MEDLINE]
Be sure to read the entire Oleander Series of articles:
See more natural health articles Here.