Anvirzel Case Reports and Related PubMed Indexed Studies on Oleander
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For a complete natural anti-cancer protocol featuring oleander, click HERE.
Unknown to many people, a patented medicine version of oleander extract named Anvirzel has been used outside the United States for over 40 years. The man who re-discovered the age old oleander remedy and developed Anvirzel is Doctor H Z Ozel. Since the medicine he used is essentially the same as the home remedy version and the even better Sutherlandia OPC supplement (http://www.tbyil.com/SOPC_Orders.htm), I thought it might be educational to list links to some of his case histories:
And here is a partial list of studies on oleander, Anvirzel and cardiac glycosides:
Newman studies involving Anvirzel, oleander and cardiac glycosides found in oleander
Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.
Integr Cancer Ther. 2007 Dec;6(4):354-64.
PMID: 18048883 [PubMed - indexed for MEDLINE]
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.
J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.
PMID: 12416031 [PubMed - indexed for MEDLINE]
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.
Biochem Pharmacol. 2001 Aug 15;62(4):469-72.
PMID: 11448457 [PubMed - indexed for MEDLINE]
Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.
Anticancer Drugs. 2000 Jul;11(6):455-63.
PMID: 11001386 [PubMed - indexed for MEDLINE]
LC/MS/MS analyses of an oleander extract for cancer treatment.
Anal Chem. 2000 Aug 1;72(15):3547-52.
PMID: 10952541 [PubMed - indexed for MEDLINE]
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
Cancer Res. 2000 Jul 15;60(14):3838-47.
PMID: 10919658 [PubMed - indexed for MEDLINE]
Cardiac glycosides as novel cancer therapeutic agents.
Mol Interv. 2008 Feb;8(1):36-49.
PMID: 18332483 [PubMed - in process]
Oleandrin-mediated oxidative stress in human melanoma cells.
J Exp Ther Oncol. 2006;5(3):167-81.
PMID: 16528968 [PubMed - indexed for MEDLINE]
Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.
Cancer Lett. 2002 Nov 28;185(2):145-51.
PMID: 12169388 [PubMed - indexed for MEDLINE]
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.
Cancer Res. 2000 Jul 15;60(14):3807-12.
PMID: 10919654 [PubMed - indexed for MEDLINE]
Be sure to read the entire Oleander Series of articles:
See more natural health articles Here.