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Oleander Found to Induce Autophagy in Pancreatic Cancer Cells
by Tony Isaacs
In a study published recently in peer reviewed
journals, an aqueous extract of the oleander plant was
found to induce
and increase autophagy
in pancreatic cancer cells. Autophagy is a
process in which a cell destroys
proteins and other substances in its cytoplasm (the
fluid inside the cell membrane but outside the nucleus),
which may lead to cell death,
as happened in the study with pancreatic cancer cells.
The study was led by noted MD Anderson researcher Doctor
Robert Newman, the lead research scientist in a number
of important studies on oleander and oleander compounds
and can be found online at:
http://health.groups.yahoo.com/pubmed/18048883?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
The new study
appears to provide yet another important piece of
evidence in understanding why oleander has proven to be
successful against many forms of cancer. In
previous studies,
oleander extracts have been shown to 1) inhibit
angiogenesis, the process where cancer produces blood
vessels and spreads, 2) inhibit the NF-kB factor in
cancer cells, which is the process that cells use to
protect themselves when they come under attack, 3)
induce apoptosis, or normal cell death, in cancer cells,
and 4) greatly stimulate immune activity.
Oleander has had
success against a broad spectrum of cancers since Doctor
H. Ziya Ozel began working with oleander extracts in
1966 in Turkey. Dr. Ozel subsequently went on to
successfully treat thousands of patients, many of whom
were in advanced stages and whom mainstream chemo and
radiation treatments had failed to help. The Salud
Integral Clinic has continued that success for the past
several years and also reports successes against a wide
variety of cancers and other cell proliferative diseases
and immune disorders.
Until recently, Phoenix Biotech was the only active manufacturer of the patented oleander medication Anvirzel, which has passed FDA phase I toxicity trials and has been used successfully outside the United States for many years, including the Salud Integral Clinic in Honduras, which Phoenix Biotech owns. Within the past month or so, Phoenix has spun off the Anvirzel portion of it's operations, including the Honduras facility, and is now concentrating all of it's efforts in oleander medicine on a new pill form and proprietary extraction method that uses liquid carbon dioxide and micro-fine particles of oleander and which is reported to result in a greater concentration of the cardiac glycosides and no loss of all the supporting compounds.
The spin off unit is named Nerium Biotechnology in Canada, whose president is former Phoenix manager Dennis Knocke. In a recent conversation with Mr. Knocke, he reported that pancreatic cancer is one of the greatest areas of success for Anvirzel, since although Anvirzel is very successful against virtually all cancers, very few other options have much success at all against the deadly and fast growing pancreatic cancer.
Pancreatic cancer, which is normally fatal within only a few months of diagnoses, yet Mr. Knocke reports that they have pancreatic cancer patients still alive years later who are healthy and doing well. He also reported speaking with two of the newer pancreatic cancer patients recently and said that both of whom were alive and doing well five months after their diagnosis. One patient's cancer had stopped growing and was stabilized and another had no signs of tumors or cancer at all now.
Other examples of Anvirzel's successes with difficult cancer include, melanoma, esophageal cancer and brain tumors. Oleander, which crosses the blood/brain barrier has been very successful against brain tumors in general and childhood brain tumors in particular.
How Oleander Extract Works Against Cancer
An
extract of oleander (Nerium oleander) that contains
oleandrin is effacious in the treatment of tumors. This
use is species-specific and is correlated with Na, K-ATPase
isoforms. Additionally, oleandrin raises the
intracellular calcium level, releases cytochrome C from
mitochondria, and induces apoptosis through a
caspase-dependent pathway.
Also, oleandrin inhibits the release of tumor growth factor bFGF from tumors. bFGF has many tumor-proliferating effects including promoting angiogenesis.
Oleandrin was determined to block the activation of NF-kB, which in turn blocks the cell-survival function of NF-kB. In addition, a non-water-soluble fraction of oleander is able to produce oxygen free-radicals in tumor cells, which may contribute to tumor cell injury and death. Oleandrin, particularly when in the context of oleandrin and oleander extract, is able to cross the blood-brain-barrier.
Evidence suggests that oleandrin and oleander extract have antiviral activity. Development continues as the oleander extract is nontoxic to normal cells and exhibits multiple antitumor activities such as inducing apoptosis, reducing molecular mechanisms of cell survival, and inhibiting tumor-promoting factor bFGF-2.
Image and Description Source: Salud Integral http://www.saludintegral.hn/
Records of the medicinal use of oleander date back at least 3500 years. The Mesopotamians in the 15th century BC believed in the healing properties of oleander and the ancient Babylonians used a mixture of oleander and licorice to treat hangovers. Roman soldiers also regularly took an oleander extract for hangovers. Pliny, the Elder of ancient Greece, wrote about the appearance and properties of oleander. Arab physicians first used oleander as a cancer treatment in the 8th century AD.
Today, the most common forms of oleander are Anvirzel, a dietary supplement from South Africa known as Sutherlandia OPC (http://www.sutherlandiaopc.com), and an increasingly popular home remedy known as "oleander soup" which is based on the original patent by Dr. Ozel.
Don't miss these related stories:
Success Against Cancer and HIV in South Africa
HIV/AIDS Clinical Trial using Oleander is 100% Successful
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