AddThis Social Bookmark Button

Click above to Bookmark this page for yourself and/or share it with your friends

Home

Click on the links below for "The Best" in:

Article Directory

Home & Herbal Remedies

Beating & Avoiding Cancer

Diets & Weight Loss

Healthy Recipes

Natural Living

Anti-Aging
& Longevity

Pets and Animals

Humor

Inspiration

The TBYIL Complete Supplement & Health Catalog

Links

Contact Us

If you would like to donate to help us keep this web site active and growing, click on the button above.   Much thanks! - Tony & Luella

The Best Years in Life Recommends:

Available Now!
Click on the image for more information

The plant you need to make your own home remedy for cancer, hepatitis-C & more may be growing in your back yard!  Read all about this proven  remedy plus much more on how to naturally beat illness and live a longer, healthier and happier life.

intraMAX

intraMAX™

The Most Scientifically Advanced, Clinically Proven,
Health Promoting Organic Nutritional Supplement Available Today!

 

Make the rest of your years

The Best Years in Life

Share

 

Drug Company Chief: Our Drugs Do Not Work on Most Patients

by Steve Connor

A senior executive with Britain's biggest drugs company has admitted that most prescription medicines do not work on most people who take them.

Allen Roses, worldwide vice-president of genetics at GlaxoSmithKline (GSK), said fewer than half of the patients prescribed some of the most expensive drugs actually derived any benefit from them.

It is an open secret within the drugs industry that most of its products are ineffective in most patients but this is the first time that such a senior drugs boss has gone public. His comments come days after it emerged that the NHS drugs bill has soared by nearly 50 per cent in three years, rising by £2.3bn a year to an annual cost to the taxpayer of £7.2bn. GSK announced last week that it had 20 or more new drugs under development that could each earn the company up to $1bn (£600m) a year.

Dr Roses, an academic geneticist from Duke University in North Carolina, spoke at a recent scientific meeting in London where he cited figures on how well different classes of drugs work in real patients. Drugs for Alzheimer's disease work in fewer than one in three patients, whereas those for cancer are only effective in a quarter of patients. Drugs for migraines, for osteoporosis, and arthritis work in about half the patients, Dr Roses said. Most drugs work in fewer than one in two patients mainly because the recipients carry genes that interfere in some way with the medicine, he said.

"The vast majority of drugs - more than 90 per cent - only work in 30 or 50 per cent of the people," Dr Roses said. "I wouldn't say that most drugs don't work. I would say that most drugs work in 30 to 50 per cent of people. Drugs out there on the market work, but they don't work in everybody."

Some industry analysts said Dr Roses's comments were reminiscent of the 1991 gaffe by Gerald Ratner, the jewelry boss, who famously said that his high street shops are successful because they sold "total crap". But others believe Dr Roses deserves credit for being honest about a little-publicized fact known to the drugs industry for many years.

"Roses is a smart guy and what he is saying will surprise the public but not his colleagues," said one industry scientist. "He is a pioneer of a new culture within the drugs business based on using genes to test for who can benefit from a particular drug."

Dr Roses has a formidable reputation in the field of "pharmacogenomics" - the application of human genetics to drug development - and his comments can be seen as an attempt to make the industry realize that its future rests on being able to target drugs to a smaller number of patients with specific genes.

The idea is to identify "responders" - people who benefit from the drug - with a simple and cheap genetic test that can be used to eliminate those non-responders who might benefit from another drug.

This goes against a marketing culture within the industry that has relied on selling as many drugs as possible to the widest number of patients - a culture that has made GSK one of the most profitable pharmaceuticals companies, but which has also meant that most of its drugs are at best useless, and even possibly dangerous, for many patients.

Dr Roses said doctors treating patients routinely applied the trial-and-error approach which says that if one drug does not work there is always another one. "I think everybody has it in their experience that multiple drugs have been used for their headache or multiple drugs have been used for their backache or whatever.

"It's in their experience, but they don't quite understand why. The reason why is because they have different susceptibilities to the effect of that drug and that's genetic," he said.

"Neither those who pay for medical care nor patients want drugs to be prescribed that do not benefit the recipient. Pharmacogenetics has the promise of removing much of the uncertainty."

Response rates

Therapeutic area: drug efficacy rate in per cent

  • Alzheimer's: 30

  • Analgesics (Cox-2): 80

  • Asthma: 60

  • Cardiac Arrhythmias: 60

  • Depression (SSRI): 62

  • Diabetes: 57

  • Hepatitis C (HCV): 47

  • Incontinence: 40

  • Migraine (acute): 52

  • Migraine (prophylaxis): 50

  • Oncology: 25

  • Rheumatoid arthritis: 50

  • Schizophrenia: 60

Originally published on Monday, December 8, 2003 by the lndependent/UK

Webmaster's notes:

"Response rate", an often misused term.  It has nothing to do with actual cure rate, and it does not necessarily indicate any significant improvement or symptom alleviation. It only means that some kind of positive response was observed, however small it may have been. When it comes to cancer, the term "response rate" is often abused to sell patients on expensive chemotherapy drugs or other mainstream treatments which often have extremely poor success rates.

The GSK vice-president blamed the drugs failure on genetics.  Yes, there must be something about natural human genetics which does not respond well to unnatural chemical compounds which attempt to force the body to function abnormally to repress symptoms of illness and in the process create more medical conditions and the need for more and more drugs.  As opposed to natural herbs, vitamins, minerals and other nutrients which help the body function normally and help prevent and actually cure illness by addressing the root causes instead of just symptoms.

See also:

Top Researcher Finds Medical Studies to be Largely Wrong or Fraudulent

New Study Says Antidepressant Drugs Next to Worthless

Latest Study: Diabetes Drugs Don't Work, Diet and Exercise are Still Best

Modern Medicine: How Healing Illness became Managing Symptoms for Profit

    

Your hosts Tony Isaacs and Luella May

Click here to visit our CureZone Health Forum: Ask Tony Isaacs: Featuring Luella May – Natural Health, Cancer, Longevity and Home & Herbal Remedies.

Misty the Found Dogs - Official Mascot of The Best Years in Life

Mountain Rose Herbs. A Herbs, Health & Harmony Com

Life Extension Highest Quality Vitamins

For the best in health information, subscribe to The Best Years in Life Newsletter featuring articles by Tony M. Isaacs

Subscribe to The Best Years in Lifeand The Oleandersoup Forum - Free Subscription

Powered by health.groups.yahoo.com

The Best Years in Life* P O Box 121 * Cooper * TX * 75432
Phone: 903-886-2436Fax: 801-926-4273

Disclaimer: The information on this page and on this website has not been evaluated by the FDA.  We do not diagnose, treat, cure or prevent illness or disease - instead, we try to help people learn how to do so themselves.  Anyone who believes they have a serious medical condition or health issue should seek diagnoses from a qualified medical professional before making any decisions on how to best address their health. We do not sell or advocate drugs, nor do we make any claims that anything advocated or sold on this website is a drug.  Furthermore, anyone contemplating using any products or information on this website must accept such use as experimental and voluntary.  No claims are made regarding the therapeutic use of the products or information on this website and all products featured or sold on this website must be considered nutritional supplements only.